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Table 4 HE4 concentrations in serum and peritoneal fluid, CA125 concentrations in serum in patients with ovarian cancer (group I) according to FIGO stage, peritoneal carcinomatosis and presence of neoplastic cells in peritoneal fluid

From: HE4 tumor marker concentration in neoplastic peritoneal effusion and in peritoneal fluid associated with benign gynecological diseases

  HE4-peritoneal fluid [pmol/L] HE4- serum [pmol/L] CA125- serum [mIU/ml]
FIGO I, II 2306 80.45 573.55
[median/95% CI] [-945.89-5558.49] [9.64-151.26] [-680.59-1827.69]
FIGO III, IV 4298 576.55 1288.45
[median/95% CI] [-67.16-8663.16] [-185.61-1338.71] [-923.67-3500.57]
p value 0.1043 0.0001 0.0975
Peritoneal carcinomatosis 4298 576.55 1288.45
YES [-67.16-8663.16] [-185.61-1338.71] [-923.67-3500.57]
[median/95% CI]    
Peritoneal carcinomatosis 2306 80.45 573.55
NO [-945.89-5558.49] [9.64-151.26] [-680.59-1827.69]
[median/95% CI]    
p value 0.1043 0.0001 0.0975
Neoplastic cells in 4412 555.6 826.5
Peritoneal fluid YES [-211.66-9035.66] [-239.48-1350.68] [-751-2404]
[median/95% CI]    
Neoplastic cells in 3236 391.5 1085.75
Peritoneal fluid NO [353.69-6116.31] [-268.25-1051.25] [-1153.45-3324.94]
[median/95% CI]    
p value 0.3868 0.2381 1.000