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Table 5 HE4 concentrations in serum and in peritoneal fluid, CA125 concentrations in serum, in patients with ovarian cancer (group I) according to cancer grade

From: HE4 tumor marker concentration in neoplastic peritoneal effusion and in peritoneal fluid associated with benign gynecological diseases

  HE4-peritoneal fluid [pmol/L] HE4- serum [pmol/L] CA125- serum [mIU/ml]
Grade 1 1844.6 49.9 75
[median/95% CI] [-844.67-4533.87] [37.41-62.39] [-58.27-208.27]
Grade 2 4180 439.3 919.5
[median/95% CI] [-28.69-8388.69] [-452.11-1330.71] [-845.7-2684.7]
p value 0.1044 0.0093 0.0137
Grade 1 1844.6 49.9 75
[median/95% CI] [-844.67-4533.87] [37.41-62.39] [-58.27-208.27]
Grade 3 4444 548.35 1770.05
[median/95% CI] [263.07-8624.93] [-235.46-1332.16] [-757.23-4297.33]
p value 0.1337 0.0011 0.0019
Grade 2 4180 439.3 919.5
[median/95% CI] [-28.69-8388.69] [-452.11-1330.71] [-845.7-2684.7]
Grade 3 4444 548.35 1770.05
[median/95% CI] [263.07-8624.93] [-235.46-1332.16] [-757.23-4297.33]
p value 0.9608 0.7587 0.8154
Grade 1 and 2 2958 97.2 215.6
[median/95% CI] [48.29-5867.7] [-13.51-207.91] [-204.63-635.83]]
Grade 3 4444 548.35 1770.05
[median/95% CI] [263.07-8624.93] [-235.46-1332.16] [-757.23-4297.33]
p value 0.4141 0.0331 0.0375