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Table 2 Fold change in gene expression comparing CsA treated B76 cells with or without 10 ng/ml IT

From: The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells

Cancer pathway

Gene

Description

Fold change

Cell adhesion

PNN

Pinin, desmosome-associated protein

2.2

FAT1

Cadherin-related tumor suppressor homolog

2.3

Cell cyclus

BRMS1

Breast cancer metastase suppressor, transcriptional repressor

2.0

NF2

Neurofibromin

2.2

Cell cyclus and transcription factor

RB1

Retinoblastoma, tumor suppressor, transcriptional repressor

2.2

TP53

Tumor suppressor, transcription factor

2.3

Cell cyclus or cell proliferation

NME1

Expressed in Non-Metastatic cells, nucleoside diphosphate kinase

3.2

Cell growth and proliferation

SSTR2

Somatostatin receptor 2, ligand somatostatin 14/28

2,1

DENR

Density-regulated protein, involved in translation

2.6

KISS1R

Receptor for KISS1

2.8

FLT4

Receptor tyrosine kinase, ligand VEGF C/D

3.1

CXCR4

CXC chemokine receptor, ligand SDF-1

3.4

EPHB2

Receptor tyrosine kinase, ligand ephrin-family members

10.3

Invasion

MMP10

Matrix metalloproteinase

2.4

MMP9

Matrix metalloproteinase

5.3

Other

METAP2

Methionyl aminopeptidase

2.1

CD82

Metastasis suppressor

2.2

CTSK

Cathepsin K, cysteine protease

4.2

NME4

Expressed in Non-Metastatic cells, nucleoside diphosphate kinase

7.6

KISS1

Metastasis suppressor

14.6

Transcription factor

MYCL1

Myc-related

-3.8

SMAD4

SMAD family member,

2.0

NR4A3

Nuclear-receptor subfamily 4 member A3, potential transcriptional activator

20.6

  1. Results from two independent experiments are analysed together.