Skip to main content

Table 1 Characteristics of studies

From: Obesity and epithelial ovarian cancer survival: a systematic review and meta-analysis

Study Country N Years of diagnosis Follow-up, yr Stage Age, yr Timing of BMI measurement BMI category Adjustment variables
Min Zhang et al. China 207 1999-2000 Minimum, 3 all stages   1. at diagnosis BMI < 20.0 Age, stage, grade, ascites, residual lesions, chemotherapy, total energy intake, menopausal status
Mean alive, 46.7 2. 5 year ago 20.0 ≤ BMI ≤ 22.4
Mean dead, 51.6 3. at age 21 y 22.5 ≤ BMI ≤ 24.9
25.0 ≤ BMI
Joanne Kotsopoulos et al. Canada 1423 1995-2004 mean 7.4 all stages under, 50.75 5 years prior to diagnosis BMI < 18.5 Age at diagnosis, BRCA mutation status, stage and histologic subtype
range, 0.59-15.72
normal, 56.23   18.5 ≤ BMI ≤ 25
  overweight, 57.84   25 ≤ BMI ≤ 30  
obese, 57.78   30 ≤ BMI
Yang Zhou et al. USA 388 1998-2003 all: 9.28 ± 8.68 all stages Median, 58.6 1. during 20s BMI < 25 Age, stage, histology, education, oral contraceptive use, menopausal status and HRT use, parity, age at first birth, family history of ovarian cancer, time from ovarian cancer diagnosis to study enrollment
BMI ≥ 25
BMI < 25: 8.67 ± 7.96 2. 5 years before diagnosis BMI < 25
BMI ≥ 25
BMI ≥ 25: 9.95 ± 9.38 3. 9 months post-chemotherapy  
Ling Yang et al. National wide (UK, Sweden, Italy, Norway, Finland) 635 1993-1995 Range, 50-74 all stages 50-74 1. Age 18 BMI < 18.5 Age at diagnosis, FIGO stage and WHO grade of differentiation
18.5 ≤ BMI ≤ 25
2. 1 year prior to ovarian cancer diagnosis 25 ≤ BMI ≤ 30
30 ≤ BMI
I. SKI’RNISDO’ TTIR et al. Sweden 635 1975-2004 Mean, 6.8 I,II Mean 60.1 at the start of the adjuvant therapy BMI < 18.5 Stage, grade, histology
18.5 ≤ BMI ≤ 25
25 ≤ BMI ≤ 30
30 ≤ BMI
Range, 1.6-17.8
Anette Kjærbye-Thygesen et al. Denmark 295 1994-1999 Median, 7.3 III Range, 35-79 1. BMI age at 20-29y BMI < 18.5 Age, radicality of surgery, histology, platinum-based chemotherapy, smoking status, continuous BMI 5 years before diagnosis
18.5 ≤ BMI ≤ 24.9
Range, 5.4-9.5 2. BMI 5years before diagnosis 25.0 ≤ BMI
Crystal P. Tyler, USA 425 1980-1982 Median, 9.7 all stages 20-54 1. adult BMI(within 6 months of diagnosis) lowest quartile (<20.7) the second (20.8–22.5) third (22.6–24.9) fourth (≥25.0) quartiles Age at diagnosis, stage at diagnosis, histologic type, oral contraceptive use, parity, menopausal status, presence of any other chronic conditions including diabetes, high blood pressure, chronic kidney disease, gallbladder disease, myocardial infarction, heart disease, high cholesterol, paralysis, or stroke
2. BMI at age 18,
3. weight change from age 18 to adult
Kirsten B. Moysich et al. USA 395 1982-1998 NA (≥9) all stages mean(SD) self-reported BMI < 18.5 age at diagnosis, FIGO stage
alive: 47.5(14.1) 1. current height and weight 18.5 ≤ BMI ≤ 25
dead: 58.3(12.3) 2. weight before dx 25 ≤ BMI ≤ 30
   30 < BMI
INGIRIDUR SKÍRNISDÓTTIR & BENGT SORBE Sweden 446 1994-2003 Mean, 3.9 all stages Mean, 62.5 at the start of the BMI ≤25 Age, stage, histology
Range, 0-12.3   range, 25-91 adjuvant therapy BMI > 25
James C. Pavelka et al. USA 149 1996-2003 Not stated III-IV Range, 18-79 first postoperative visit BMI < 18.5 nil
18.5 ≤ BMI ≤ 25
25 ≤ BMI ≤ 30
30 < BMI
Schlumbrecht, M. USA 127 2002-2007 mean, 3.1 (0.3-7.2) not stated not stated not stated BMI < 18.5 not stated
18.5 ≤ BMI ≤ 25
25 ≤ BMI ≤ 30
30 < BMI
Dolecek, T.A. et al. USA 341 1994-1998 Not stated I-IV Range, 18-74 Self-reported BMI at diagnosis BMI < 18.5 Age, race, stage, grade, residual lesions, smoking status, oral contraceptive use, parity
18.5 ≤ BMI ≤ 25
25 ≤ BMI ≤ 30
30 ≤ BMI
Fotopoulou, C. et al. Germany 306 2000-2010 11.7 months (0.1-62.9) I-IV 58(18–92) Not stated BMI < 25 Residual tumor, grade, positive lymph node status, age, FIGO stage, Ascites, IMO level 2/3 involvement, nonserous histology, distant metastasis
BMI ≥ 25
Lamkin, D.M. et al. USA 74 2001-2005 Not stated I-IV 62(33–87) Not stated BMI as continuous variable None (univariate analysis)
Nagle, C.M. et al. Australia 609 1990-1993 Median 7.3 yrs (5–8.3) I-IV 18-79 Prior to illness BMI <22.2 FIGO stage, age, grade, total energy intake (Kilocalories), BMI, residual, ascites, smoking status, parity and length of OCP use
22.2-25.8
BMI > 25.8
Schlumbrecht, M.P. et al. USA 194 1977-2009 Median f/u 60.9 months (1–383) I-IV 44.9(14–79) 8 wks after primary surgical intervention BMI <25 Stage, Taxane, Current alcohol use, year of diagnosis, current smoker, age at diagnosis, hormone tx after adjuvant ctx
25 ≤ BMI < 30
30 ≤ BMI < 35
35 ≤ BMI
Schildkraut, J.M. et al. USA 197 1980-1982 Not stated I-IV 20-54 At diagnosis BMI > 27.9 None (univariate analysis)
  1. IMO, Intraoperative Mapping of Ovarian Cancer.