Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer

Table 3 Comparison of SNP genotypes between ovarian cancer patients and women without any malignancy

rs1467465	Genotype frequency			Allele frequency		Allele positivity
	GG	AA	AG	G	A	G	A
Cases	0.35	0.15	0.50	0.60	0.40	0.85	0.65
Controls	0.47	0.13	0.41	0.67	0.33	0.88	0.53
P		0.13	0.03		0.04		0.02
OR		n.s.	1.63		1.37		1.632
C.I. 95 %		n.s.	1.045-2.045		1.013-1.853		1.072-2.483
rs12048235	Genotype frequency			Allele frequency		Allele positivity
	GG	AA	AG	G	A	G	A
Cases	0.42	0.12	0.46	0.65	0.35	0.88	0.58
Controls	0.42	0.15	0.45	0.63	0.37	0.85	0.59
P		0.48	0.87		0.61		0.90
OR		n.s.	n.s.		n.s.		n.s.
C.I. 95 %		n.s.	n.s.		n.s.		n.s.

After tests for deviation from Hardy-Weinberg equilibrium were conducted, allele frequency, allele positivity and genotype frequencies were determined. Odds ratio (OR) was calculated using the more frequent homozygous genotypes as reference group. Bold p-values were considered to be statistically significant. n.s.=not significant.

ISSN: 1757-2215