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Table 1 Development of cells resistant to CDDP and PTX

From: Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity

Cells IC50 CDDP (μM) IC50 PTX (nM) CDP (CDDP + PTX)
IGROV-1 5.40 ± 0.57 60.9 ± 1.22 0.24 ± 0.04
IGROV-1 PTES 12.1 ± 1.01b 554 ± 15.5b 0.52 ± 0.04b
SKOV-3 15.6 ± 1.20 78.0 ± 6.40 0.16 ± 0.20
SKOV-3 PTES 64.1 ± 4.10a 1230 ± 300c 1.20 ± 0.20c
  1. CDP = Combination Dose Proportion. CDP is considered a combination of doses and exposure times that when equal to 1 are clinically achievable (CDP = 1 means 20 μM CDDP for 1 h plus 100 nM PTX for 3 h). For instance, a CDP of 0.5 means that the inhibition of growth by 50% was achieved using half the concentration of each of the drugs (i.e., 10 μM CDDP for 1 h plus 50 nM PTX for 3 h). ap < 0.001; bp < 0.01; cp < 0.05 (Student’s t-test) compared to parental cells.