Cells | IC50 CDDP (μM) | IC50 PTX (nM) | CDP (CDDP + PTX) |
---|
IGROV-1 | 5.40 ± 0.57 | 60.9 ± 1.22 | 0.24 ± 0.04 |
IGROV-1 PTES | 12.1 ± 1.01b | 554 ± 15.5b | 0.52 ± 0.04b |
SKOV-3 | 15.6 ± 1.20 | 78.0 ± 6.40 | 0.16 ± 0.20 |
SKOV-3 PTES | 64.1 ± 4.10a | 1230 ± 300c | 1.20 ± 0.20c |
- CDP = Combination Dose Proportion. CDP is considered a combination of doses and exposure times that when equal to 1 are clinically achievable (CDP = 1 means 20 μM CDDP for 1 h plus 100 nM PTX for 3 h). For instance, a CDP of 0.5 means that the inhibition of growth by 50% was achieved using half the concentration of each of the drugs (i.e., 10 μM CDDP for 1 h plus 50 nM PTX for 3 h). ap < 0.001; bp < 0.01; cp < 0.05 (Student’s t-test) compared to parental cells.