Skip to main content

Table 2 Antiprogestin-induced growth inhibition toward CDDP and PTX resistant cells

From: Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity

Cells

RU-38486

ORG-31710

CDB-2914

CDB-4124

OH-4124

CDB-4453

IGROV-1

11.7 ± 1.80

21.6 ± 1.10

15.5 ± 1.10

35.5 ± 3.90

28.6 ± 3.40

30.6 ± 2.70

IGROV-1 PTES

10.7 ± 1.20

15.2 ± 1.40c

12.5 ± 1.10

21.3 ± 1.80c

25.9 ± 2.40

25.6 ± 2.60

SKOV-3

15.7 ± 1.90

17.2 ± 4.20

31.5 ± 3.10

43.6 ± 5.10

84.2 ± 9.80

44.9 ± 4.60

SKOV-3 PTES

16.0 ± 2.10

19.2 ± 2.70

31.2 ± 1.80

47.4 ± 3.90

58.4 ± 8.30

52.9 ± 2.10

  1. Data shown are the IC50 (μM) expressed as the mean ± s.e.m (n = 3); OH-4124 indicates 17-α-hydroxy CDB-4124. cp < 0.05 (Student’s t-test) compared to parental cells.
Back to article page

Journal of Ovarian Research

ISSN: 1757-2215

Contact us