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Table 2 Antiprogestin-induced growth inhibition toward CDDP and PTX resistant cells

From: Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity

Cells RU-38486 ORG-31710 CDB-2914 CDB-4124 OH-4124 CDB-4453
IGROV-1 11.7 ± 1.80 21.6 ± 1.10 15.5 ± 1.10 35.5 ± 3.90 28.6 ± 3.40 30.6 ± 2.70
IGROV-1 PTES 10.7 ± 1.20 15.2 ± 1.40c 12.5 ± 1.10 21.3 ± 1.80c 25.9 ± 2.40 25.6 ± 2.60
SKOV-3 15.7 ± 1.90 17.2 ± 4.20 31.5 ± 3.10 43.6 ± 5.10 84.2 ± 9.80 44.9 ± 4.60
SKOV-3 PTES 16.0 ± 2.10 19.2 ± 2.70 31.2 ± 1.80 47.4 ± 3.90 58.4 ± 8.30 52.9 ± 2.10
  1. Data shown are the IC50 (μM) expressed as the mean ± s.e.m (n = 3); OH-4124 indicates 17-α-hydroxy CDB-4124. cp < 0.05 (Student’s t-test) compared to parental cells.