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Table 1 Patient characteristics

From: Preoperative HE4 and ROMA values do not improve the CA125 diagnostic value for borderline tumors of the ovary (BOT) – a study of the TOC Consortium

Parameter N Median Range
Age (years)    
Whole collective 167 47 16-87
Benign diseases 104 48 19-86
BOT without InvImp 48 44 16-83
BOT with InvImp 15 55 25-87
Preoperative HE4 (pmol/L)    
Benign diseases 104 50 20-1410
BOT without InvImp 48 52 29-2135
BOT with InvImp 15 74 35-461
Preoperative CA125 (IU/ml)    
Benign diseases 104 21 5-334
Non-invasive BOT 48 25 3-725
Invasive BOT 15 63 12-259
Histological type of BOT N (without InvImp) N (with InvImp) N (total)
Serous 29 10 39
Mucinous 18 4 22
Endometrioid 0 1 1
Mixed 1 0 1
Types of benign diseases N %  
Benign ovarian lesions 48 49.92  
Ovarian thecofibroma 2 2.08  
Leiomyomata 55 57.2  
  1. Abbreviations: BOT: borderline ovarian tumors; InvImp: invasive implants; HE4: human epididymis protein 4; CA125: cancer antigen 125.