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Table 2 IVF and ovarian cancer (Cohort studies)

From: Fertility drugs, reproductive strategies and ovarian cancer risk

Study Treatments Population Results
Venn et al.[44] 1995 IVF 29666 women, 3 cancers in exposed, 3 cancers in unexposed SIR in exposed = 1.7 (CI 95%: 0.55-5.27) SIR in unexposed = 1.62 (95% CI: 0.52-5.02) RR exposed vs unexposed = 1,45 (95% CI: 0.28-7.55)
Venn et al.[45] 1999 IVF 29700 women, 7 ovarian cancers in exposed, 6 in unexposed SIR in exposed = 0,88 (95% CI: 0,42- 1.84) SIR in unexposed = 1.16 (95% CI: 0.52-2.59)
Dor et al.[47] 2002 IVF Retrospective cohort of 5026 women, 1 ovarian cancer case SIR in exposed = 0.57 (95% CI: 0.01-3.20)
Klip et al.[48] 2002 IVF 23592 women, 17 ovarian cancers No differences in risk exposed vs unexposed Detailed information obtained through questionnaires and from medical records
Lerner Geva et al.[43] 2003 IVF 1082 women, 3 ovarian cancers SIR in exposed = 5.0 (95% CI: 1.02-14.6) SIR = 1.67 (0.02-9.27) when cancers developing within 1 year were excluded No untreated group Registry match
Kallen et al.[46] 2011 IVF 24058 women, 26 ovarian cancers RR exposed vs unexposed = 2.09 (95% CI: 1,39-3.12)
van Leeuwen et al.[49] 2011 IVF 19146 IVF women, 6006 subfertile women not treated with IVF Risk of borderline ovarian tumours increased in the IVF group compared with the general population. SIR = 1.76 (95% CI: 1.16-2.56). The overall SIR for invasive ovarian cancer was not significantly elevated, but increased with longer follow-up after first IVF. SIR = 3.54 (95% CI: 1.62-6.72) after 15 years.
Yli-kuha et al.[50] 2013 IVF 9175 women, 9 invasive ovarian cancers, 4 borderline ovarian tumors OR for invasive cancers = 2.57 (95% CI: 0.69-9.23) OR for borderline tumors = 1.68 (95% CI: 0.31-9.27)
Brinton et al.[51] 2013 IVF 87403 women, 45 ovarian cancers Global HR =1.58 (95% CI: 0.75-3.29), HR among women receiving ≥ 4 IVF cycles =1.78 95% CI: 0.76-4.13).
  1. Abbreviations: IVF = in vitro fertilization, SIR = standardized index ratio, CI = confidence interval, RR = relative risk, OR = odds ratio, HR = hazard ratio.