Grade ≥ 3 AE, % | GOG-0218[21] | ICON7[22] | OCEANS[41] | AURELIA[26] | |||||
---|---|---|---|---|---|---|---|---|---|
CP + placebo | CP + Bev | CP + Bev → Bev | CP | CP + Bev → Bev | CG + placebo | CG + Bev | CTx | CTx + Bev | |
(n = 601) | (n = 607) | (n = 608) | (n = 753) | (n = 745) | (n = 233) | (n = 247) | (n = 182) | (n = 179) | |
Neutropenia | 57.7a | 63.3a | 63.3a | 15 | 17 | – | – | – | – |
Pain | 41.6b | 41.5b | 47.0b | – | – | – | – | – | – |
Thrombocytopenia | – | – | – | 2 | 3 | 34 | 40 | – | – |
Hypertension | 7.2b | 16.5b | 22.9b | <1 | 6 | 0.4 | 17.8 | – | – |
VTE | 5.8c | 5.3c | 6.7c | 2 | 4 | – | – | 4 | 3 |
Febrile neutropenia | 3.5c | 4.9c | 4.3c | 2 | 3 | – | – | 1 | 1 |
Proteinuria | 0.7 | 0.7 | 1.6 | <1 | 1 | 0.9 | 9.7 | – | – |
Bleeding (non-CNS) | 0.8 | 1.3 | 2.1 | <1 | 1 | 0.9 | 5.7 | 1 | 1 |
Wound healing complications | 2.8c | 3.6c | 3.0c | <1 | 1 | – | – | – | – |
ATE | 0.8c | 0.7c | 0.7c | 1 | 3 | – | – | 0 | 2 |
GI events | 1.2b | 2.8b | 2.6b | <1 | 1 | 0 | 0 | – | – |
Epistaxis | – | – | – | – | – | 0.4 | 4.9 | – | – |
Abscess/fistula | – | – | – | 1 | 1 | 0.4c | 1.6c | – | – |
RPLS | 0 | 0.2c | 0.2c | 0 | 0 | 0 | 0.8c | 0 | 1 |
CHF | – | – | – | <1 | <1 | – | – | 1 | 1 |
CNS bleeding | 0 | 0 | 0.3c | 0 | <1 | – | – | – | – |