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Table 2 Preoperative markers, bcl-2 and cathepsin–L serum concentrations depending on the method of treatment

From: Serum HE4, CA125, YKL-40, bcl-2, cathepsin-L and prediction optimal debulking surgery, response to chemotherapy in ovarian cancer

 

Primary optimal cytoreduction

Neoadjuvant chemotherapy

p

CA125 [IU/ml]

   

Mean

1206.79

2432.28

 

Median

190.7

600

p = 0.000191

Range

(7.38-21442)

(49.22-22982)

 

HE4 [pmol/l]

   

Mean

78.87

602.45

 

Median

32.19

551.69

p = 0.000004

Range

(2.5-775.79)

(45.82-1574.89)

 

YKL-40 [ng/ml]

   

Mean

108.13

203.96

 

Median

70.50

200.24

p = 0.003991

Range

(16.42-417.27)

(45.02-437.01)

 

Cathepsin-L [ng/ml]

   

Mean

13.12

12.75

 

Median

12.64

11.05

p = 0.5305

Range

(8.42-28.87)

(8.53-46.45)

 

bcl-2 [ng/ml]

   

Mean

20.86

22.75

 

Median

19.63

19.34

p = 0.5741

Range

(17.52-24.19)

(4.88-81.02)