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Table 3 Preoperative markers, bcl-2 and cathepsin–L serum concentrations depending on the method of treatment at serous tumors only

From: Serum HE4, CA125, YKL-40, bcl-2, cathepsin-L and prediction optimal debulking surgery, response to chemotherapy in ovarian cancer

 

Primary optimal cytoreduction

Neoadjuvant chemotherapy

p

CA125 [IU/ml]

   

Mean

455.1

2661.46

 

Median

167.25

600.0

p = 0.0019

Range

(15.81-2377.0)

(49.22-22982.0)

 

HE4 [pmol/l]

   

Mean

87.62

560.7

 

Median

24.78

564.72

p = 0.0009

Range

(2.5-775.79)

(45.82-1310.69)

 

YKL-40 [ng/ml]

   

Mean

128.73

203.37

 

Median

84.23

200.24

p = 0.005

Range

(16.42-417.27)

(45.02-437.01)

 

Cathepsin-L [ng/ml]

   

Mean

12.95

12.81

 

Median

84.23

10.98

p = 0.8125

Range

(8.42-28.87)

(8.53-46.45)

 

bcl-2 [ng/ml]

   

Mean

12.01

23.98

 

Median

20.98

20.07

p = 0.6913

Range

(11.27-45.53)

(4.88-81.02)