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Table 4 Preoperative markers, bcl-2 and cathepsin–L serum concentrations depending on response to chemotherapy

From: Serum HE4, CA125, YKL-40, bcl-2, cathepsin-L and prediction optimal debulking surgery, response to chemotherapy in ovarian cancer

 

S

IS

p

S

R

p

IS

R

p

S

IS+R

p

CA125 [IU/ml]

  

p = 0.038

  

p = 0.1852

  

p = 0.2261

  

p = 0.0324

Median

575.77

1338.79

575.77

949.01

1338.79

949.01

575.77

1058.15

Range

(7.38-2743.5)

(464.43-4882.06)

(7.38-2743.5)

(49.23-22982)

(464.43-4882.06)

(49.23-22982)

(7.38-2743.5)

(49.23-22982)

HE4 [pmol/l]

  

p = 0.045

  

p = 0.268

  

p = 0.127

  

p = 0.0888

Median

254.42

566.22

254.42

271.32

566.22

271.32

254.42

349.96

Range

(2.5-1310.69)

(106.96-1574.89)

(2.5-1310.69)

(2.5-590.13)

(106.96-1574.89)

(2.5-590.13)

(2.5-1310.69)

(2.5-1574.89)

YKL-40 [ng/ml]

  

p = 0.062

  

0 = 0.0218

  

p = 0.2452

  

p = 0.0339

Median

131.04

143.55

131.04

231.02

143.55

231.02

131.04

193.53

Range

(16.42-417.27)

(55.06-235.01)

(16.42-417.27)

(63.98-437.01)

(55.06-235.01)

(63.98-437.01)

(16.42-417.27)

(55.06-437.01)

Cathepsin-L [ng/ml]

  

p = 0.3242

  

p = 0.1734

  

p = 0.2759

  

p = 0.3461

Median

12.72

12.26

12.72

11.68

12.26

11.68

12.72

11.84

Range

(8.42-46.45)

(9.74-14.98)

(8.42-46.45)

(9.34-18.17)

(9.74-14.98)

(9.34-18.17)

(8.42-46.45)

(9.34-18.17)

bcl-2 [ng/ml]

  

p = 0.1010

  

p = 0.0719

  

p = 0.1073

  

p = 0.2777

Median

24.37

32.48

24.37

16.73

32.48

16.73

24.37

20.84

Range

(18.91-29.84)

(9.89-81.02)

(18.91-29.84)

(4.88-30.94)

(9.89-81.02)

(4.88-30.94)

(18.91-29.84)

(4.88-81.02)

  1. S-platinum sensitive; IS-platinum resistant; R-platinum refractory.