Figure 1

miR-490-3P decreased sensitivity of the A2780 and A2780/Taxol cells to paclitaxel. RT-PCR results showed that A2780/Taxol has higher miR-490-3P mRNA expression level than A2780 (A). CCK-8 cell proliferation assays show that after miR-490-3P transfection, the sensitivity of both A2780 and A2780/Taxol cells transfected with miR-490-3P mimics to paclitaxel was decreased compared with that treated with NC or Mock cells (B). Results are representative of three separate experiments; data are expressed as the mean ± standard deviation.