Figure 2

miR-490-3P down-regulate MDR1/P-gp and GST-π expression. RT-PCR results showed that after microRNA 490-3P transfection, the mRNA expression levels of MDR1 and GST-π in A2780 and A2780/Taxol cell lines were higher than negative control cells or mock cells (A, p < 0.05). Western blot analysis showed that the protein expression levels of P-gp and GST-π were also higher than those of negative control cells and mock cells (B, p < 0.05).