Table 2 Genotypic distribution of polymorphisms in the IRS1 and IRS2 genes between the PCOS group and control group
PCOS group | Control group | p a | OR (95% C.I.) | p b | |
|---|---|---|---|---|---|
IRS-1 Gly972Arg | (n = 248) | (n = 92) | |||
GG | 220 (88.7%) | 84 (91.3%) | 0.622 | 1 | |
GA | 28 (11.3%) | 8 (8.7%) | 1.03 (0.42-2.53) | 0.942 | |
IRS-2 Gly1057Asp | (n = 95) | (n = 74) | |||
GG | 12 (12.6%) | 25 (33.8%) | 1 | ||
GA | 18 (18.9%) | 13 (17.6%) | 0.004 | 2.77 (0.87-8.81) | 0.084 |
AA | 65 (68.4%) | 36 (48.6%) | 4.08 (1.60-10.41) | 0.003 | |
GG + GA | 30 (31.6%) | 38 (51.4%) | 0.015 | 1 | |
AA | 65 (68.4%) | 36 (48.6%) | 2.52 (1.21-5.26) | 0.014 | |
IRS-1 and IRS-2 | (n = 95) | (n = 74) | |||
GG/GG + GA | 26 (27.4%) | 35 (47.3%) | 1 | ||
GA/AA | 58 (61.1%) | 38 (51.4%) | 0.003 | 2.49 (1.16-5.37) | 0.019 |
GA and AA | 11 (11.6%) | 1 (1.4%) | 11.87 (1.21-116.84) | 0.034 |