Table 1 Ongoing phase I and phase II trials of therapies targeting the Notch pathway
Drug | Target | ClinicalTrials.gov identifier | n | Delivery | Disease site | Monotherapy or combination |
|---|---|---|---|---|---|---|
MK-0752 | γ-secretase | NCT01098344 | 60 | Oral | Unresectable pancreatic cancer | Combination with gemcitabine |
RO4929097 | γ-secretase | NCT01071564 | 46 | Oral | Unresectable breast cancer | Combination with vismodegib |
RO4929097 | γ-secretase | NCT01238133 | 14 | Oral | Neoadjuvant breast cancer | Combination with carboplatin and paclitaxel |
RO4929097 | γ-secretase | NCT01122901 | 60 | Oral | Glioblastoma | Monotherapy |
RO4929097 | γ-secretase | NCT01151449 | 30 | Oral | Breast cancer | Monotherapy |
NCT01120275 | 24 | Â | Melanoma | |||
NCT01232829 | 21 | Â | Pancraetic cancer | |||
RO4929097 | γ-secretase | NCT01119599 | 34 | Oral | Glioblastoma | Combination with radiation therapy and temozolomide |
RO4929097 | γ-secretase | NCT01193881 | 39 | Oral | Lung cancer | Combination with erlotinib |
RO4929097 | γ-secretase | NCT01158274 | 30 | Oral | Refractory solid tumors | Combination with capecitabine |
RO4929097 | γ-secretase | NCT01141569 | 5 | Oral | Renal cell cancer | Monotherapy |
RO4929097 | γ-secretase | NCT01189240 | 13 | Oral | Glioblastoma | Combination with bevacizumab |
RO4929097 | γ-secretase | NCT01200810 | 78 | Oral | Refractory prostate cancer | Combination with bicalutamide |
RO4929097 | γ-secretase | NCT01175343 | 37 | Oral | Refractory ovarian, fallopian tube or peritoneal cancer | Monotherapy |
BMS-906024 | γ-secretase | NCT01653470 | 95 | IV | Advanced/metastatic solid tumors | Combination with weekly paclitaxel; 5-FU and irinotecan; carboplatin and paclitaxel |
BMS-906024 | γ-secretase | NCT01292655 | 110 | IV | Advanced/metastatic solid tumors | Monotherapy |
BMS-906024 | γ-secretase | NCT01363817 | 42 | IV | T-cell leukemia or lymphoma | Monotherapy |
BMS-986115 | γ-secretase | NCT01986218 | 40 | Oral | Advanced/metastatic solid tumors | Monotherapy |
PF-03084014 | γ-secretase | NCT01981551 | 17 | Oral | Desmoid tumors | Monoterapy |