SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

Table 2 Percentage of mice at different stages of the estrous cycle among groups

Age and estrous cycle stage	NC (n = 8)	CR (n = 8)	CHF (n = 8)	SRT (n = 6)	NAM (n = 6)
Age and estrous cycle stage	%	%	%	%	%
2 months
Regular cycling	100	100	87.5	100	100
Irregular cycling	0	0	12.5	0	0
3 months
Regular cycling	100	75	87.5	66.7	83.3
Irregular cycling	0	25	12.5	33.3	16.7
4 months
Regular cycling	100	62.5	0	0	0
Irregular cycling	0	37.5	100	100	100
5 months
Regular cycling	66.7	12.5	0	0	0
Irregular cycling	33.3	87.5	100	100	100
6 months
Regular cycling	75	12.5	0	0	0
Irregular cycling	25	87.5	100	100	100
7 months
Regular cycling	75	37.5	0	0	0
Irregular cycling	25	62.5	100	100	100
8 months
Regular cycling	75	37.5	0	16.7	0
Irregular cycling	25	62.5	100	83.3	100

Note: The dietary treatment started at the beginning of 8 weeks (2 months) of age and stopped at the end of 32 weeks (8 months) of age. The drug administration started at the 26 weeks of age and lasted for 6 weeks.

ISSN: 1757-2215