Figure 2

Differential expression of KLK6 and KLK7 genes is significantly selective for OVC versus 18 other human cancer types. Over 390 cDNAs derived from 19 different cancer tissues and corresponding normal tissues were assayed by RT-qPCR to quantitatively measure KLK6 (A) and KLK7 (B) gene expression. The fold change represents the level of gene expression in cancer normalized against the corresponding normal tissue. The mean number of samples used in the assay was 15 for cancer and five for corresponding normal tissues. The statistical significance of differential KLK6 and KLK7 expression in OVC (solid black bar) over other cancer types (solid gray bars) was determined to be p <0.001 (indicated by *) by one-way ANOVA (SigmaStat). Abbreviations for cancer types are Ov = ovarian, AG = Adrenal Gland, Br = Breast, CV = Cervix, Co = Colon, En = Uterine Endometrium, Kd = Kidney, Es = Esophagus, Lv = Liver, Lu = Lung, LN = Lymph Node, LT = Lymphoid Tissue, Pn = Pancreas, Pr = Prostate, St = Stomach, Te = Testis, TG = Thyroid Gland, UB = Urinary Bladder, and Ut = Uterus.