Figure 3

KLK6 and KLK7 gene expression is subtype-specific (A) and increases progressively in advanced stages (B) and higher grades (C) of ovarian tumors. Gene expression levels quantitatively measured by qRT-PCR in cDNAs derived from ovarian tumors versus normal ovarian tissue. The fold change level is represented by the height of each histogram and the fold change is indicated in white boldface within the back bars for each subtype (error bars are indicated). Abbreviations for OVC subtypes in (A) are PS = Papillary Serous, S = Serous, E = Endometrioid, M = Mucinous, C = Clear Cell, MC = Metastatic Carcinoma (adenocarcinoma of the ovary, metastatic), B = Borderline and MT = Mixed Type. Abbreviations used in (B) are G1, G2, and G3, which represent progressive tumor grades; GB is the grade corresponding to borderline subtypes. In (C), the four progressive tumors stages are denoted as I, II, III, and IV. The number of ovarian tumor samples analyzed is given in parentheses.