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Table 2 Gene set enrichment analysis of the transcriptome of CRCs of individual oocytes developing into embryos selected for transfer

From: The transcriptome of corona radiata cells from individual MІІ oocytes that after ICSI developed to embryos selected for transfer: PCOS women compared to healthy women

Pathway

No of genes enriched/total number of genes in the pathway

FDR

NES

Reactome Cell Cycle

127/421

0.001

0.42

Reactome G2 M Checkpoints

17/45

0.001

0.61

KEGG DNA Replication

20/36

0.001

0.65

Reactome Meiotic Recombination

35/86

0.001

0.59

Reactome Packaging of Telomere Ends

25/48

0.001

0.63

Reactome Activation of the Pre Replicative Complex

14/31

0.001

0.60

Reactome RNA POL Ι RNA POL ΙΙΙ and Mitochondrial Transcription

45/122

0.001

0.53

Reactome RNA POL Ι Transcription

35/89

0.001

0.55

Reactome RNA POL Ι Promotor Opening

32/62

0.001

0.64

Reactome Activation of ATR in Response to Replication Stress

15/38

0.001

0.63

Reactome Deposition of new CENPA containing Nucleosomes at the Centromere

34/64

0.001

0.60

Reactome DNA strand Elongation

20/30

0.001

0.69

Reactome Telomere Maintenance

39/75

0.001

0.61

Reactome Cell Cycle Mitotic

94/325

0.01

0.41

Reactome Meiosis

45/116

0.01

0.49

Reactome Amyloids

34/83

0.01

0.51

Reactome lagging strand synthesis

12/19

0.01

0.69

Reactome Mitotic M M G1 Phases

55/137

0.03

0.42

Reactome Mitotic Prometaphase

32/87

0.03

0.47

Reactome DNA replication

56/192

0.03

0.42

Reactome Meiotic Synapsis

34/73

0.03

0.50

Reactome Chromosome Maintenance

55/122

0.03

0.42

Reactome Extension of Telomeres

13/27

0.03

0.59

Reactome Transcription

61/210

0.04

0.41

  1. PCOS women compared controls (n = 6 PCOS arrays vs n = 6 control arrays). Enriched pathways with FDR <0.05 were listed. NES = normalized enrichment score. All enriched pathways were upregulated in PCOS CRC samples.