A prospective cohort study of dietary indices and incidence of epithelial ovarian cancer

Table 2 Hazard ratios (95% confidence intervals) for the association between 2-year lagged cumulative updated AHEI-2010 and ovarian cancer from 1986 through 2010 among women in the NHS

		AHEI-2010
	N cases	≤42	>42-48	>48-53	>53-59	>59	P trend
# of cases		106	125	159	153	153
Person-years		294,805	294,224	293,771	293,500	293,282
Age-adjusted	696	1.00 (Ref)	1.04 (0.80,1.35)	1.29 (1.00,1.65)	1.17 (0.91,1.50)	1.12 (0.87,1.45)	0.30
Multivariable^*	696	1.00 (Ref)	1.02 (0.78,1.32)	1.23 (0.96,1.59)	1.11 (0.86,1.43)	1.03 (0.80,1.34)	0.77
Invasive*	592	1.00 (Ref)	1.10 (0.83,1.46)	1.34 (1.02,1.76)	1.17 (0.88,1.54)	1.00 (0.75,1.34)	0.90
Borderline*	57	1.00 (Ref)	0.72 (0.32,1.67)	0.79 (0.34,1.83)	0.87 (0.39,1.95)	0.87 (0.38,1.95)	0.88
Serous/poorly differentiated*	435	1.00 (Ref)	1.19 (0.86,1.65)	1.32 (0.96,1.82)	1.17 (0.84,1.62)	0.99 (0.71,1.39)	0.69
Non-serous*	148	1.00 (Ref)	0.65 (0.37,1.12)	0.93 (0.56,1.53)	0.79 (0.47,1.33)	0.87 (0.53,1.44)	0.83
Rapidly fatal*	247	1.00 (Ref)	1.11 (0.72,1.70)	1.18 (0.78,1.80)	1.06 (0.70,1.63)	0.93 (0.61,1.44)	0.60
Less aggressive*	274	1.00 (Ref)	1.15 (0.76,1.74)	1.55 (1.05,2.29)	1.24 (0.82,1.86)	1.02 (0.66,1.55)	0.98

*Adjustment factors are listed in the statistical analyses section.
P values for heterogeneity by tumor subtype were 0.91, 0.98, and 0.71 for invasive versus borderline, serous/poorly differentiated versus non-serous, and rapidly fatal versus less aggressive tumors, respectively.

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