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Table 2 Hazard ratios (95% confidence intervals) for the association between 2-year lagged cumulative updated AHEI-2010 and ovarian cancer from 1986 through 2010 among women in the NHS

From: A prospective cohort study of dietary indices and incidence of epithelial ovarian cancer

   AHEI-2010
  N cases ≤42 >42-48 >48-53 >53-59 >59 P trend
# of cases   106 125 159 153 153  
Person-years   294,805 294,224 293,771 293,500 293,282  
Age-adjusted 696 1.00 (Ref) 1.04 (0.80,1.35) 1.29 (1.00,1.65) 1.17 (0.91,1.50) 1.12 (0.87,1.45) 0.30
Multivariable* 696 1.00 (Ref) 1.02 (0.78,1.32) 1.23 (0.96,1.59) 1.11 (0.86,1.43) 1.03 (0.80,1.34) 0.77
Invasive* 592 1.00 (Ref) 1.10 (0.83,1.46) 1.34 (1.02,1.76) 1.17 (0.88,1.54) 1.00 (0.75,1.34) 0.90
Borderline* 57 1.00 (Ref) 0.72 (0.32,1.67) 0.79 (0.34,1.83) 0.87 (0.39,1.95) 0.87 (0.38,1.95) 0.88
Serous/poorly differentiated* 435 1.00 (Ref) 1.19 (0.86,1.65) 1.32 (0.96,1.82) 1.17 (0.84,1.62) 0.99 (0.71,1.39) 0.69
Non-serous* 148 1.00 (Ref) 0.65 (0.37,1.12) 0.93 (0.56,1.53) 0.79 (0.47,1.33) 0.87 (0.53,1.44) 0.83
Rapidly fatal* 247 1.00 (Ref) 1.11 (0.72,1.70) 1.18 (0.78,1.80) 1.06 (0.70,1.63) 0.93 (0.61,1.44) 0.60
Less aggressive* 274 1.00 (Ref) 1.15 (0.76,1.74) 1.55 (1.05,2.29) 1.24 (0.82,1.86) 1.02 (0.66,1.55) 0.98
  1. *Adjustment factors are listed in the statistical analyses section.
  2. P values for heterogeneity by tumor subtype were 0.91, 0.98, and 0.71 for invasive versus borderline, serous/poorly differentiated versus non-serous, and rapidly fatal versus less aggressive tumors, respectively.