A prospective cohort study of dietary indices and incidence of epithelial ovarian cancer

Table 3 Hazard ratios (95% confidence intervals) for the association between 2-year lagged cumulative updated HEI-2005 and ovarian cancer from 1986 through 2010 among women in the NHS

		HEI-2005
	N cases	≤56	>56-63	>63-68	>68-74	>74	P trend
N cases		127	117	129	162	161
Person-years		294,749	294,665	294,337	293,738	292,082
Age-adjusted	696	1.00 (Ref)	0.82 (0.63,1.05)	0.85 (0.66,1.09)	0.99 (0.78,1.26)	0.92 (0.72,1.17)	0.98
Multivariable*	696	1.00 (Ref)	0.79 (0.61,1.03)	0.82 (0.63,1.06)	0.93 (0.72,1.20)	0.85 (0.65,1.12)	0.57
Invasive*	592	1.00 (Ref)	0.80 (0.60,1.05)	0.80 (0.60,1.05)	0.91 (0.69,1.20)	0.86 (0.64,1.15)	0.60
Borderline*	57	1.00 (Ref)	1.00 (0.45,2.24)	1.11 (0.50,2.43)	0.97 (0.42,2.20)	0.54 (0.20,1.43)	0.31
Serous/poorly differentiated*	435	1.00 (Ref)	0.81 (0.59,1.13)	0.91 (0.66,1.25)	0.91 (0.66,1.26)	0.90 (0.64,1.27)	0.79
Non-serous*	148	1.00 (Ref)	0.77 (0.46,1.31)	0.70 (0.41,1.21)	1.03 (0.62,1.69)	0.83 (0.49,1.43)	0.81
Rapidly fatal*	247	1.00 (Ref)	0.76 (0.51,1.14)	0.62 (0.40,0.94)	0.67 (0.44,1.02)	0.75 (0.50,1.13)	0.15
Less aggressive*	274	1.00 (Ref)	0.79 (0.52,1.18)	0.89 (0.60,1.32)	1.08 (0.73,1.59)	0.85 (0.556,1.29)	0.89

*Adjustment factors are listed in the Statistical Analyses section.
P values for heterogeneity by tumor subtype were 0.42, 0.95, and 0.32 for invasive versus borderline, serous/poorly differentiated versus non-serous, and rapidly fatal versus less aggressive tumors, respectively.

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