Figure 2
From: Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1α pathway in human ovarian cancer in vitro
SDHB silencing contributed to ovarian cancer cell proliferation in SKOV3 and A2780 cells. (A, B) Cell proliferation was assessed following SDHB silencing treatment for 6 days by CCK8. Mean ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001. (C) 48 h post transfection, p-ERK, ERK were examined by western blot. (D, E) 48 h post-transfection, SKOV3 and A2780 cells were treated with DDP at indicated concentration for 24 h, cleaved caspase 3, total caspase 3, and Bcl-2 were then analysed by western blot.