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Table 2 Summary of the FSHR N680S polymorphism with poor and hyper-responders

From: Evaluating influence of the genotypes in the follicle-stimulating hormone receptor (FSHR) Ser680Asn (rs6166) polymorphism on poor and hyper-responders to ovarian stimulation: a meta-analysis

  

S allele

N allele

NS genotype

  

Test of association

Test of heterogeneity

Test of association

Test of heterogeneity

Test of association

Test of heterogeneity

 

N

OR

95% CI

pA

pB

I2

AM

OR

95% CI

pA

pB

I2

AM

OR

95% CI

pA

pB

I2

AM

Poor responders

All

11

1.61

0.94-2.74

0.08

<0.0001

80

R

0.95

0.66-1.37

0.78

0.002

65

R

0.93

0.60-1.46

0.75

<0.0001

80

R

Outliers omitted

--

0.90

0.66-1.23

0.52*

0.16

36

F

1.02

0.82-1.26

.88**

0.10

42

F

0.82

0.66-1.02

.08***

0.78

0

F

NHC

7

1.24

0.76-2.05

0.39

0.03

57

R

0.99

0.60-1.62

0.97

0.009

65

R

0.88

0.69-1.13

0.32

0.79

0

F

Hyper-responders

All

6

1.47

1.05-2.04

0.02

0.23

28

F

0.64

0.46-0.88

0.007

0.19

32

F

1.10

0.83-1.46

0.50

0.37

7

F

NHC

4

1.57

1.11-2.23

0.01

0.33

13

F

0.68

0.38-1.20

0.18

0.07

57

R

1.03

0.76-1.40

0.83

0.69

0

F

  1. NHC: Non-Hispanic Caucasian; N: number of studies; OR: odds ratio; CI: confidence interval; pA: p value for association with significance set at <0.05; pB: p value for heterogeneity with significance set at <0.10; I2 values as measure of heterogeneity are considered low (<44%), moderate (45-74%) or high (>75%); values in bold indicate significant associations; *N = 7; **N = 8; ***N = 10; AM: Analysis Model; R: Random-effects; F: Fixed-effects.
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Journal of Ovarian Research

ISSN: 1757-2215

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