| |
S allele
|
N allele
|
NS genotype
|
---|
| |
Test of association
|
Test of heterogeneity
|
Test of association
|
Test of heterogeneity
|
Test of association
|
Test of heterogeneity
|
---|
|
N
|
OR
|
95% CI
|
pA
|
pB
|
I2
|
AM
|
OR
|
95% CI
|
pA
|
pB
|
I2
|
AM
|
OR
|
95% CI
|
pA
|
pB
|
I2
|
AM
|
---|
Poor responders
|
All
|
11
|
1.61
|
0.94-2.74
|
0.08
|
<0.0001
|
80
|
R
|
0.95
|
0.66-1.37
|
0.78
|
0.002
|
65
|
R
|
0.93
|
0.60-1.46
|
0.75
|
<0.0001
|
80
|
R
|
Outliers omitted
|
--
|
0.90
|
0.66-1.23
|
0.52*
|
0.16
|
36
|
F
|
1.02
|
0.82-1.26
|
.88**
|
0.10
|
42
|
F
|
0.82
|
0.66-1.02
|
.08***
|
0.78
|
0
|
F
|
NHC
|
7
|
1.24
|
0.76-2.05
|
0.39
|
0.03
|
57
|
R
|
0.99
|
0.60-1.62
|
0.97
|
0.009
|
65
|
R
|
0.88
|
0.69-1.13
|
0.32
|
0.79
|
0
|
F
|
Hyper-responders
|
All
|
6
|
1.47
|
1.05-2.04
|
0.02
|
0.23
|
28
|
F
|
0.64
|
0.46-0.88
|
0.007
|
0.19
|
32
|
F
|
1.10
|
0.83-1.46
|
0.50
|
0.37
|
7
|
F
|
NHC
|
4
|
1.57
|
1.11-2.23
|
0.01
|
0.33
|
13
|
F
|
0.68
|
0.38-1.20
|
0.18
|
0.07
|
57
|
R
|
1.03
|
0.76-1.40
|
0.83
|
0.69
|
0
|
F
|
- NHC: Non-Hispanic Caucasian; N: number of studies; OR: odds ratio; CI: confidence interval; pA: p value for association with significance set at <0.05; pB: p value for heterogeneity with significance set at <0.10; I2 values as measure of heterogeneity are considered low (<44%), moderate (45-74%) or high (>75%); values in bold indicate significant associations; *N = 7; **N = 8; ***N = 10; AM: Analysis Model; R: Random-effects; F: Fixed-effects.