Skip to main content

Table 2 Summary of the FSHR N680S polymorphism with poor and hyper-responders

From: Evaluating influence of the genotypes in the follicle-stimulating hormone receptor (FSHR) Ser680Asn (rs6166) polymorphism on poor and hyper-responders to ovarian stimulation: a meta-analysis

   S allele N allele NS genotype
   Test of association Test of heterogeneity Test of association Test of heterogeneity Test of association Test of heterogeneity
  N OR 95% CI pA pB I2 AM OR 95% CI pA pB I2 AM OR 95% CI pA pB I2 AM
Poor responders
All 11 1.61 0.94-2.74 0.08 <0.0001 80 R 0.95 0.66-1.37 0.78 0.002 65 R 0.93 0.60-1.46 0.75 <0.0001 80 R
Outliers omitted -- 0.90 0.66-1.23 0.52* 0.16 36 F 1.02 0.82-1.26 .88** 0.10 42 F 0.82 0.66-1.02 .08*** 0.78 0 F
NHC 7 1.24 0.76-2.05 0.39 0.03 57 R 0.99 0.60-1.62 0.97 0.009 65 R 0.88 0.69-1.13 0.32 0.79 0 F
Hyper-responders
All 6 1.47 1.05-2.04 0.02 0.23 28 F 0.64 0.46-0.88 0.007 0.19 32 F 1.10 0.83-1.46 0.50 0.37 7 F
NHC 4 1.57 1.11-2.23 0.01 0.33 13 F 0.68 0.38-1.20 0.18 0.07 57 R 1.03 0.76-1.40 0.83 0.69 0 F
  1. NHC: Non-Hispanic Caucasian; N: number of studies; OR: odds ratio; CI: confidence interval; pA: p value for association with significance set at <0.05; pB: p value for heterogeneity with significance set at <0.10; I2 values as measure of heterogeneity are considered low (<44%), moderate (45-74%) or high (>75%); values in bold indicate significant associations; *N = 7; **N = 8; ***N = 10; AM: Analysis Model; R: Random-effects; F: Fixed-effects.