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Table 2 Frequency of the most common BRCA1 and BRCA2 mutations among French Canadian women with ovarian cancer

From: A targeted analysis identifies a high frequency of BRCA1 and BRCA2 mutation carriers in women with ovarian cancer from a founder population

Histological subtype Number of women with ovarian cancer (fallopian tube and primary peritoneal cancer) BRCA1 positive (%) BRCA2 positive (%) BRCA1 and BRCA2 positive (%)
C4446T 2953delGTAinsC Total 8765delAG G6085T 3398del5 E3002K Total
Serous 369 (9) 12 (3.3)* 1 (0.3) 13 (3.5) 4 (1.1) 5 (1.4)* 3 (0.8)* 5 (1.4)* 17 (4.6) 30 (8.1)
Endometrioid 30 (0) 1 (3.3) 0 1 (3.3) 0 0 0 0 0 1 (3.3)
Mixed cell 32 (0) 2 (6.3) 1 (3.1) 3 (9.4) 0 0 0 0 0 3 (9.4)
Undifferentiated 8 (1) 0 0 0 0 0 0 0 0 0
All types 439 (10) 15 (3.4) 2 (0.5) 17 (3.9) 4 (0.9) 5 (1.1) 3 (0.7) 5 (1.1) 17 (3.9) 34 (7.7)
  1. *One grade 2 mutation-positive carrier found among each of these mutation-positive carriers.