Table 2 Frequency of the most common BRCA1 and BRCA2 mutations among French Canadian women with ovarian cancer
Histological subtype | Number of women with ovarian cancer (fallopian tube and primary peritoneal cancer) | BRCA1 positive (%) | BRCA2 positive (%) | BRCA1 and BRCA2 positive (%) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
C4446T | 2953delGTAinsC | Total | 8765delAG | G6085T | 3398del5 | E3002K | Total | |||
Serous | 369 (9) | 12 (3.3)* | 1 (0.3) | 13 (3.5) | 4 (1.1) | 5 (1.4)* | 3 (0.8)* | 5 (1.4)* | 17 (4.6) | 30 (8.1) |
Endometrioid | 30 (0) | 1 (3.3) | 0 | 1 (3.3) | 0 | 0 | 0 | 0 | 0 | 1 (3.3) |
Mixed cell | 32 (0) | 2 (6.3) | 1 (3.1) | 3 (9.4) | 0 | 0 | 0 | 0 | 0 | 3 (9.4) |
Undifferentiated | 8 (1) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
All types | 439 (10) | 15 (3.4) | 2 (0.5) | 17 (3.9) | 4 (0.9) | 5 (1.1) | 3 (0.7) | 5 (1.1) | 17 (3.9) | 34 (7.7) |