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Table 4 Features of carriers based on BRCA1 and BRCA2 mutation status

From: A targeted analysis identifies a high frequency of BRCA1 and BRCA2 mutation carriers in women with ovarian cancer from a founder population

Gene mutated

Histological subtype

Number of mutation carriers (n = 439) (%)

Age of diagnosis, years (%)

Tumour grade (%)

Disease stage 1 (%)

<60 (n = 196)

≥60 (n = 243)

G1 (n = 13)

G2 (n = 93)

G3 (n = 312)

Un-classified (n = 21)

I,II (n = 78)

III,IV (n = 360)

BRCA1

Serous

15

9

6

0

1

14

0

3

12

 

Endometrioid

2

2

0

0

0

2

0

0

2

 

Mixed cell

4

3

1

0

0

4

0

0

4

 

Undifferentiated

0

0

0

0

0

0

0

0

0

 

All types

21

14

7

0

1

20

0

3

18

BRCA2

Serous

17

12

5

0

3

13

1

1

16

 

Endometrioid

0

0

0

0

0

0

0

0

0

 

Mixed cell

0

0

0

0

0

0

0

0

0

 

Undifferentiated

1

0

1

0

0

1

0

0

1

 

All types

18

12

6

0

3

14

1

1

17

BRCA1 or BRCA2

All types

39 (8.9)

26 (13.3)

13 (5.3)

0

4 (4.3)

34 (10.9)

1 (4.8)

4 (5.1)

35 (9.7)

None

 

400 (91.1)

170 (86.7)

230 (94.7)

13 (100)

89 (95.7)

278 (89.1)

20 (95.2)

74 (94.9)

325 (90.3)

  1. 1Staging information was not available for a women found mutation-negative who had a serous ovarian carcinoma diagnosed at 91 years of age.