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Table 4 Features of carriers based on BRCA1 and BRCA2 mutation status

From: A targeted analysis identifies a high frequency of BRCA1 and BRCA2 mutation carriers in women with ovarian cancer from a founder population

Gene mutated Histological subtype Number of mutation carriers (n = 439) (%) Age of diagnosis, years (%) Tumour grade (%) Disease stage 1 (%)
<60 (n = 196) ≥60 (n = 243) G1 (n = 13) G2 (n = 93) G3 (n = 312) Un-classified (n = 21) I,II (n = 78) III,IV (n = 360)
BRCA1 Serous 15 9 6 0 1 14 0 3 12
  Endometrioid 2 2 0 0 0 2 0 0 2
  Mixed cell 4 3 1 0 0 4 0 0 4
  Undifferentiated 0 0 0 0 0 0 0 0 0
  All types 21 14 7 0 1 20 0 3 18
BRCA2 Serous 17 12 5 0 3 13 1 1 16
  Endometrioid 0 0 0 0 0 0 0 0 0
  Mixed cell 0 0 0 0 0 0 0 0 0
  Undifferentiated 1 0 1 0 0 1 0 0 1
  All types 18 12 6 0 3 14 1 1 17
BRCA1 or BRCA2 All types 39 (8.9) 26 (13.3) 13 (5.3) 0 4 (4.3) 34 (10.9) 1 (4.8) 4 (5.1) 35 (9.7)
None   400 (91.1) 170 (86.7) 230 (94.7) 13 (100) 89 (95.7) 278 (89.1) 20 (95.2) 74 (94.9) 325 (90.3)
  1. 1Staging information was not available for a women found mutation-negative who had a serous ovarian carcinoma diagnosed at 91 years of age.