Ingenuity Pathway Analysis (IPA) analysis. (A) Top 5 canonical pathways enriched by observed metabolite alterations. (B) The top network includes aspects of carbohydrate metabolism, energy production, and small molecule biochemistry. Networks, constructed from the IPA knowledgebase by connecting the altered molecules, are not limited by canonical pathway boundaries. Abbreviations: ERK 1/2: extracellular-signal-related kinases 1 and 2; CPT1:.carnitine palmitoyltransferase 1; ACAC: acetyl CoA carboxylase; sPLA2: soluble phospholipase A2; PmCa: plasma membrane calcium ATPase; HMGCoA: 3-hydroxy-3-methyl-glutaryl-CoA; Acox: acyl CoA; Ces: cholesterol esters.