Methionine metabolism pathway. A bio-chart of the methionine metabolism pathway and the related pathways of folate, glutathione and polyamine biosynthesis. RED text metabolites represent elevated mean intensity in C200 cells compared to A2780 cells, whereas GREEN text represent reduced intensity. The catalyzing enzymes are texted BROWN. BLUE arrows and text convey the requirement of that pathway metabolite towards the indicated macromolecule synthesis. Abbreviations: DHF: dihydrofolate; THF: tetrahydrofolate; f-THF: formate-THF; m-THF: methylene-THF; SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; CH3: methyl group; GSH: glutathione, GSSG: oxidized glutathione.