Radiochemotherapy and anti-inflammatory drug injection strategy. SCID-Beige inbred mice received a chemodrug (cisplatin) for three consecutive days, −D1, D0, and D1, and A2780 cells were transplanted 24 hrs after the first cisplatin injection. Similarly, SCID-Beige inbred mice underwent irradiation at 1000 cGy on –D1, prior to A2780 cell injection. SCID-Beige inbred mice also received anti-inflamatory drugs (ibuprofen or dexamethasone) for five consecutive injections (−12 hrs, 0 hrs, +12 hrs, +24 hrs, +36 hrs) and underwent irradiation at 1000 cGy at 0 hrs, followed immediately by A2780 celltransplantation. All drugs were injected at doses explained in the figure. All mice were sacrificed 48 hours after the injection of A2780 cells, and bone marrows, spleens, livers, and lungs were collected. The presence of ovarian cells (i.e., murine–human chimeras) was evaluated by the level of human α-satellite DNA expression.