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Table 3 List of molecular pathways containing genes with activated (↑) and repressed (↓) level of mRNA in DHT treated compared to CTL rat ovary groups

From: Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids

Biosynthesis of steroids

CYP51, ↓HMGCR, ↓SQLE, ↓HSD17B7, ↓FDFT1, ↓LSS, MVD, ↓FDPS, ↓IDI1, ↓SC5DL, ↓EBP, ↓SC4MOL, ↓TM7SF2, ↓DHCR24, ↓NSDHL

TGF-beta signaling pathway

↑INHBB, ↑INHBA, ↑AMH, ↑BMP2, ↑FOXO1, ↑FOXP2, ↓FKBP1A,↑ INHA, BAMBI, ↑CITED1, ↓CITED2

Leukocyte transendothelial migration

↑CXCL12, ↓THY1, ↓BCAR1, ↓PECAM1,↓ CXCR4, ↑CLDN11, ↑MYL9, ↓SIPA1

Cholesterol biosynthesis

MVD, ↓HMGCR, ↓HMGCS1, ↓FDPS, ↓IDI1, ↓FDFT1

Pyruvate metabolism

ME1, ↓DLAT, ↑ALDH1B1, ↓ME2, ↓ACAT2, ↓ACSS2, ↑ME3

Glycerophospholipid metabolism

PLA2G1B, ↑PLA2G2A, ↓GPD1, ↓CDS1,↓ PCYT2, ↑ETNK2, ↑CRLS1

Complement and coagulation cascades

A2M, ↓C2, ↓PLAU, ↑TFPI, ↑MASP1,↓ CFB, ↓C1QA

Glycolysis/Gluconeogenesis

HK1, ↓HK2, ↓DLAT, ↑FBP2, ↑ALDH1B1,↓ACSS2

Adipocytokine signaling pathway

↑JAK2, ↓NFKBIB, ↑IRS3, ↓ACSL3, ↓ADIPOR, ↑STK11

Butanoate metabolism

HMGCS1, ↓AACS, ↑ALDH1B1, ↓ACAT2, ↑ACSM5

Terpenoid biosynthesis

SQLE, ↓FDFT1, ↓FDPS, ↓IDI1

Ether lipid metabolism

PLA2G1B, ↑PLA2G2A, ↑PAFAH1B3, ↑ENPP6

Citrate cycle (TCA cycle)

ACLY, ↓IDH1, ↓DLAT, ↓DLST

Androgen and estrogen metabolism

↑SRD5A1, ↓ HSD17B1, ↓HSD17B7, ↓HSD3B6

Androgen/estrogene/progesterone biosynthesis

HSD3B6, ↓CYP11A1, ↓NSDHL, ↓CYP19A1

Glutathione metabolism

GPX1, ↓IDH1, ↓GSTT1, ↑GPX7

Lysine degradation

↑ALDH1B1, ↓DLST, ↓ACAT2, ↑MGC109340

Fatty acid metabolism

↑ACSL3, ↓ACAA2, ↑ALDH1B1, ↓ACAT2

Valine, leucine and isoleucine degradation

HMGCS1, ↓ACAA2, ↑ALDH1B1, ↓ACAT2