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Table 4 The diagnostic criteria of the ROC curve for M-CSF and in combination with HE4 and CA 125 in epithelial ovarian cancer patients

From: M-CSF in a new biomarker panel with HE4 and CA 125 in the diagnostics of epithelial ovarian cancer patients

Epithelial ovarian cancer

The ROC criteria

M-CSF

HE4

CA 125

M-CSF+ HE4

M-CSF+ CA 125

HE4 + CA 125

M-CSF+ HE4 + CA 125

stage I

AUC

0.7676*

0.7285*

0.7653*

0.8536*

0.8702*

0.8326*

0.9069*

SE

0.0681

0.0708

0.0416

0.0496

0.0433

0.0538

0.0353

95% C.I.

0.604-0.871

0.590-0.867

0.692-0.794

0.756-0.951

0.785-0.955

0.728-0.938

0.838-0.976

p AUC = 0.5

<0.001

0.0013

0.0005

<0.001

<0.001

<0.001

<0.001

stage II

AUC

0.8662*

0.7647*

0.8653*

0.9008*

0.9113*

0.9208*

0.9443*

SE

0.0483

0.0562

0.0389

0.0387

0.0393

0.0314

0.0265

95% C.I.

0.772-0.961

0.654-0.876

0.814-0.968

0.825-0.977

0.834-0.988

0.859-0.983

0.892-0.966

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

stage III

AUC

0.9336*

0.9257*

0.9114*

0.9624*

0.9608*

0.9764*

0.9714*

SE

0.0317

0.0291

0.0428

0.0250

0.0302

0.0302

0.0222

95% C.I.

0.871-0.996

0.869-0.984

0.828-0.995

0.913-1.011

0.902-1.020

0.903-1.020

0.928-1.015

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

stage IV

AUC

0.9096*

0.9125*

0.9474*

0.9872*

0.9665*

0.9422*

0.9894*

SE

0.0414

0.0428

0.0260

0.0086

0.0214

0.0353

0.0083

95% C.I.

0.829-0.991

0.829-0.996

0.897-0.998

0.970-1.004

0.925-1.008

0.873-1.012

0.973-1.006

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

Total group

AUC

0.8562*

0.8324*

0.9277*

0.9257*

0.9271*

0.9182*

0.9529*

SE

0.0316

0.0321

0.0221

0.0212

0.0225

0.0223

0.0172

95% C.I.

0.794-0.918

0.769-0.895

0.884-0.972

0.884-0.967

0.883-0.971

0.874-0.963

0.919-0.967

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

Serous epithelial

AUC

0.9058*

0.8722*

0.9046*

0.9491*

0.9558*

0.9390*

0.9659*

SE

0.0306

0.0347

0.0301

0.0199

0.0199

0.0233

0.0160

95% C.I.

0.846-0.966

0.805-0.964

0.846-0.964

0.910-0.989

0.917-0.995

0.893-0.985

0.930-0.997

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

Endome-trioid epithelial

AUC

0.7983*

0.7845*

0.9129*

0.8978*

0.8926*

0.8927*

0.9374*

SE

0.0491

0.0467

0.0305

0.0331

0.0343

0.0330

0.0241

95% C.I.

0.702-0.894

0.694-0.876

0.854-0.973

0.833-0.963

0.825-0.960

0.828-0.958

0.890-0.985

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

  1. (C.I. – confidence intervals of AUC).
  2. *statistically significant when comparing tested parameters AUC’s with 0.5 AUC.
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Journal of Ovarian Research

ISSN: 1757-2215

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