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Table 4 The diagnostic criteria of the ROC curve for M-CSF and in combination with HE4 and CA 125 in epithelial ovarian cancer patients

From: M-CSF in a new biomarker panel with HE4 and CA 125 in the diagnostics of epithelial ovarian cancer patients

Epithelial ovarian cancer The ROC criteria M-CSF HE4 CA 125 M-CSF+ HE4 M-CSF+ CA 125 HE4 + CA 125 M-CSF+ HE4 + CA 125
stage I AUC 0.7676* 0.7285* 0.7653* 0.8536* 0.8702* 0.8326* 0.9069*
SE 0.0681 0.0708 0.0416 0.0496 0.0433 0.0538 0.0353
95% C.I. 0.604-0.871 0.590-0.867 0.692-0.794 0.756-0.951 0.785-0.955 0.728-0.938 0.838-0.976
p AUC = 0.5 <0.001 0.0013 0.0005 <0.001 <0.001 <0.001 <0.001
stage II AUC 0.8662* 0.7647* 0.8653* 0.9008* 0.9113* 0.9208* 0.9443*
SE 0.0483 0.0562 0.0389 0.0387 0.0393 0.0314 0.0265
95% C.I. 0.772-0.961 0.654-0.876 0.814-0.968 0.825-0.977 0.834-0.988 0.859-0.983 0.892-0.966
p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
stage III AUC 0.9336* 0.9257* 0.9114* 0.9624* 0.9608* 0.9764* 0.9714*
SE 0.0317 0.0291 0.0428 0.0250 0.0302 0.0302 0.0222
95% C.I. 0.871-0.996 0.869-0.984 0.828-0.995 0.913-1.011 0.902-1.020 0.903-1.020 0.928-1.015
p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
stage IV AUC 0.9096* 0.9125* 0.9474* 0.9872* 0.9665* 0.9422* 0.9894*
SE 0.0414 0.0428 0.0260 0.0086 0.0214 0.0353 0.0083
95% C.I. 0.829-0.991 0.829-0.996 0.897-0.998 0.970-1.004 0.925-1.008 0.873-1.012 0.973-1.006
p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Total group AUC 0.8562* 0.8324* 0.9277* 0.9257* 0.9271* 0.9182* 0.9529*
SE 0.0316 0.0321 0.0221 0.0212 0.0225 0.0223 0.0172
95% C.I. 0.794-0.918 0.769-0.895 0.884-0.972 0.884-0.967 0.883-0.971 0.874-0.963 0.919-0.967
p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Serous epithelial AUC 0.9058* 0.8722* 0.9046* 0.9491* 0.9558* 0.9390* 0.9659*
SE 0.0306 0.0347 0.0301 0.0199 0.0199 0.0233 0.0160
95% C.I. 0.846-0.966 0.805-0.964 0.846-0.964 0.910-0.989 0.917-0.995 0.893-0.985 0.930-0.997
p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Endome-trioid epithelial AUC 0.7983* 0.7845* 0.9129* 0.8978* 0.8926* 0.8927* 0.9374*
SE 0.0491 0.0467 0.0305 0.0331 0.0343 0.0330 0.0241
95% C.I. 0.702-0.894 0.694-0.876 0.854-0.973 0.833-0.963 0.825-0.960 0.828-0.958 0.890-0.985
p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
  1. (C.I. – confidence intervals of AUC).
  2. *statistically significant when comparing tested parameters AUC’s with 0.5 AUC.