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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas

Fig. 2

Rb1, P16 and ER expression according to tumor grade in representative cases of ovarian serous carcinomas. Ovarian epithelial carcinomas of different histologic subtypes and grades in tissue microarray slide were used. Anti-Rb1 rabbit polyclonal, anti-P16 and mouse anti-human ER primary antibodies were used for immunohistochemistry. Notice high nuclear expression of Rb1 in low grade serous carcinoma (LGSC) compared to weak positive staining in high grade serous carcinoma (HGSC). The reverse is true for p16 with high expression in HGSC compared to negative staining in LGSC. ER shows high expression score in LGSC compared to low score in HGSC

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