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Table 3 Rb1 expression according to ER H-score by IHC in high and low grade ovarian serous carcinomas

From: Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas

Tumor type

HGSC n = 67 (p-value*)

LGSC n = 10 (p-value*)

Rb1+/ER- (H-score 0–25)

23/67 (34 %) (P = 0.16)

2/10 (20 %) (p = 0.26)

Rb1+/ER (H-score 26–75)

4/67 (6 %) (p = 0.02)

0 (p = 1)

Rb1+/ ER (H-score 76–150)

8/67 (12 %) (p = 0.03)

1/10 (10 %) (p = 1)

Rb1+/ ER (H-score > 150)

2/67 (3 %) (p = 0.61)

3/10 (30 %) (<0.001)

  1. Abbreviations: HGSC High grade serous carcinoma, LGSC Low grade serous carcinoma. *Chi square or Fisher exact test comparing HGSC or LGSC against all ovarian epithelial carcinomas studied (n = 130)