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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Novel reversible selective inhibitor of CRM1 for targeted therapy in ovarian cancer

Fig. 2

The inhibitory effects of nuclear export by S109 is reversible. a S109 and LMB inhibit nuclear export of RanBP1. SKOV-3 Cells were treated with indicated doses of S109 or LMB for 2 h. Fixed cells were stained for RanBP1 and DAPI and analyzed by fluorescence microscopy. b Reversible effect of S109 on the localization of RanBP1. Cells were incubated with indicated doses of S109 or LMB. After 2 h, the drugs were washed out and fresh medium was added. Cells were incubated for 1 h and then analyzed by fluorescence microscopy

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