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Table 3 Subgroup analyses of CTCs/DTCs

From: Prognostic value of circulating tumor cells and disseminated tumor cells in patients with ovarian cancer: a systematic review and meta-analysis

Subgroup analysis

PFS/DFS

OS

 

No. of Studies (sample size)

HR (95 % CI)

Model

P value

P-H

Begg’s test, p value

No. of Studies (sample size)

HR (95 % CI)

Model

P value

P-H

Begg’s test, p value

Total (CTCs and DTCs)

6 (885)

1.99 [1.59, 2.50]

FE

<.0001

0.1047

0.0167

7 (965)

1.94 [1.56 2.40]

FE

<.0001

0.7704

0.2389

Sampling from BM (DTCs)

2 (181)

1.60 [1.17, 2.19]

FE

0.0034

0.4417

1.000

2 (181)

1.89 [1.33, 2.68]

FE

0.0004

0.9687

1.0000

Sampling from PB (CTCs)

4 (704)

2.52 [1.83, 3.48]

FE

<.0001

0.2064

0.3333

5 (784)

1.97 [1.50, 2.58]

FE

<.0001

0.5147

0.0833

Total (IHC and RT-PCR)

5 (756)

1.91 [1.51, 2.40]

FE

<.0001

0.2037

0.0833

6 (818)

1.89 [1.52, 2.36]

FE

<.0001

0.7839

0.7194

Detected DTCs by IHC

3 (397)

1.70 [1.33, 2.19]

FE

<.0001

0.5934

1.0000

3 (397)

1.96 [1.48, 2.60]

FE

0.0004

0.9314

1.0000

Detected CTCs by RT-PCR

2 (359)

3.45 [1.95, 6.24]

FE

<.0001

0.9452

1.0000

3 (439)

1.78 [1.24, 2.54]

FE

0.0017

0.3463

0.3333

  1. FE Fixed-Effects; P-H P-Heterogeneity