Fig. 4

Cellular metabolism profiles of OVCAR-5 cell line with single and combination treatment of EGCG + paclitaxel (a), EGCG + cisplatin (b), EGCG + everolimus (c), paclitaxel + cisplatin (d) paclitaxel + everolimus (e) and cisplatin + everolimus (f) in 2D cell monolayers (black bar) and 3D ECM (grey bar). The representative graph in 2D cell monolayers and 3D ECM was the relative value to the control. The statistical difference of single and combination in 2D cell monolayers (* P < 0.05, student’s t-test) and 3D ECM ( ^# P < 0.05, student’s t-test) was compared between the control and treated cells. Data was obtained from at least four independent experiments with triplicate