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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancer

Fig. 4

NF-κB activity in ID8-NGL tumors is not inhibited by treatment with TQ and/or cisplatin. BL/6 mice were injected with ID8-NGL cells and treated with vehicle, TQ (20 mg/kg), cisplatin (2 mg/kg) or the combination for 30 days. a Luciferase assays of NF-κB reporter activity in harvested ID8-NGL tumors. b QPCR analysis of the established NF-κB target genes, TNF-α and IL-1β, in harvested tumors. Relative expression was calculated using corresponding GAPDH levels as the internal control. Values are mean + SD for 5 mice per group; *p < 0.01 relative to vehicle; all p values determined by Mann–Whitney test

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