Fig. 1

Immunohistochemical analysis of IL-6 expression in human epithelial ovarian cancer (EOC) tissue Representative micrographs show high (A) and low (B) levels of the immunohistochemical expression of IL-6 in the high-grade serous EOC tissue (magnification = 40x) (a) represents the negative control. Graphs (C) and (D) demonstrate the upregulation of IL-6 in EOC as compared with the normal ovarian tissue. Data are presented as mean expression score ± SE (C) and maximum and minimum expression score (D). Significant values (<0.05) are marked by asterisks. Graph (E) indicates the percentage of cases with higher (T > N), lower (T < N) or equal (T = N) intratumoral levels of IL-6 when the protein expressions in tumoral and matched normal ovarian tissues were compared. Graph (F) shows the mean expression scores of IL-6 in different subgroups of EOC as mean expression score ± SE. Graph (G) depicts maximum and minimum expression scores of IL-6 in different subgroups of EOC. HGS: high grade serous; LGS: low grade serous; M: mucinous; HGE: high grade endometrioid; LGE: low grade endometrioid; C: clear cell; O: others. Magnification = 40x