Fig. 1

MicroRNA (miRNA) expression profiling of SEOC and normal ovarian tissues. a The principal component analysis (PCA) plot generated a clear segregation between SEOC (green) and normal ovarian tissues (red). b The volcano plot representing significance of identified miRNAs which are differentially expressed with p < 0.05. The up-regulated miRNAs are shown in red while down-regulated miRNAs are shown in blue. c Hierarchical clustering of the 38 differentially expressed (DE) miRNAs. Samples are designated along the vertical axis and clustered by the colour bar in between the dendrogram and heatmap. Red denotes normal ovary group while yellow denotes SEOC group. The colour key illustrates the miRNAs relative expression across all samples. Red illustrates higher expression level than the mean and yellow illustrates lower expression level than the mean