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Fig. 5 | Journal of Ovarian Research

Fig. 5

From: MicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancer

Fig. 5

MiR-200c down-regulates DLC-1, promotes proliferation and colony formation but suppresses SEOC cells invasion and migration. a The alignment of nucleotide sequence between the miR-200c and complementary sequence on DLC-1 3’untranslated region (UTR) interactions. The colon (:) symbol denotes wobble base pair between guanine (G) and uracil (U) nucleotides. b QPCR showing down-regulated DLC-1 mRNA following transient transfection of miR-200c mimic and inhibitor in SEOC cells. c The miR-200c mimic transfection promoted cell proliferation and inhibition of miR-200c reduced cell proliferation. d Up-regulation of miR-200c enhanced colony formation but (e) down-regulation of miR-200c caused colony formation suppression. f miR-200c over-expression increased cell invasion whereas miR-200c down-regulation reduced cell invasion. g MiR-200c inhibited cell migration in SEOC cells and (h) The inhibition of miR-200c induced cell migration. All experiments were conducted in triplicates. Data are presented as mean with error bars representing the S.D. Statistical analysis of the microRNA functional studies were done using t-test. (*p < 0.05, **p < 0.01, ***p < 0.001)

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