Fig. 4

Cisplatin@CB[7] retains its enhanced activity in the disseminated ovarian cancer model. a Delay on intraperitoneal tumour growth over 14 days of A2780-Rab25 i.p. xenografts following injection on day 1 of saline (Ctl), cisplatin at 6 mg/kg, cisplatin@CB[7] at 34 mg/kg (equivalent to 6 mg/kg of cisplatin), and subcubtaneous injection of cisplatin@CB[7] at 34 mg/kg (equivalent to 6 mg/kg of cisplatin). SEM bars are shown. b Relative body weights over fourteen days after treatment. c Comparison between cisplatin treatment injected through s.c. or i.p. route in A2780 subcutaneous xenografts measured for tumour volume by calipers after cisplatin injection on day 0. Body weight was monitored for the duration of the experiment. SEM bars are shown. d Relative body weights over fourteen days after treatment. e Representatitve H&E images of orthotopic ovarian tumours (T) from the control, cisplatin, cisplatin@CB[7] injected i.p. and cisplatin@CB[7] injected s.c. cohorts. Necrotic regions (N) are observed in all cisplatin cohorts