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Table 1 Cases of mitotically active cellular fibroma of the ovary

From: Mitotically active cellular fibroma of the ovary: a case report and literature review

Author

Year

Case no.

Age (y)

Side

Size(cm)

Tumor marker

Mitoses (MF/10HPF)

Surgery

Additional therapy

Positive

Weak, focally

Negative

ki-67 index

Follow-up time (mo)

Status at last follow-up

Kaku et al. [2]

2007

1

32

Left

6.6 × 6,0 × 4.4

CA 125(-), CEA(-)

17

LSO

-

SMA, HHF35, vimentin, PR, ki-67

ER

desmin

ND

12

NED

Bucella et al. [3]

2009

2

65

ND

10(1st), 12 × 10 × 9 (2nd), 8 (3rd)

-

4

TAH, BSO, reduction twice

Tamoxifen

vimentin

α-inhibin, actin, CD99

desmin, h-caldesmon, CD10, HMB-45, c-kit

9

60 + 6 + 6

Recurrence twice, NED

Monterio et al. [4]

2012

3

13

Right

19 × 15 × 12

CA125(453), AFP(-), HCG(-), CEA(-), CA199(-), CA153(-)

5–7

RSO, OMT

-

ND

ND

ND

ND

36

NED

Wu et al. [5]

2014

4

76

Right

9 × 6 × 5

CA125(-), CA153(-), CA199 (-),AFP (-), CEA(-), SCC(-)

5–9

TAH, BSO

-

vimentin, α-inhibin, ER, PR

CD56, CD99

cytokeratin, EMA, CD10, HMB45, S-100, calretinin, CD34, CD117, Dog-1

10

ND

ND

Zong et al. [6]

2014

5

39

Left

10 × 7 × 4

CA125(41), HCG(-)

3–5

TAH, LSO, OMT, LD

-

CD99, CK, SMA, vimentin, ER, PR, S-100

-

CD10, CK7, EMA, desmin

10

66

NED

This case

2015

6

36

Right

6

CEA(-), CA125(-), CA199(-), SCC(-), HCG(-), AFP(-)

10

RSO

-

vimentin, PR, CD10, CD56, WT1

α-inhibin

AE1/AE3, ER, calretinin, EMA

8.7

6

NED

  1. ND, not described; CEA, carcinoembryonic antigen; (-), within normal range; AFP, α-feto protein; HCG, human chorionic gonadotropin; SCC, squamous cell carcinoma; TAH, total abdominal hysterectomy; BSO, bilateral salpingo-oophorectomy; OMT, omentectomy; LD, lymphadenectomy; SMA, smooth muscle actin; HHF35, anti-muscle-specific actin (clone; HHF35); PR, progresterone receptor; ER, estrogen receptor; CK, cytokeratin; WT, Wilms tumor; HMB, human melanoma black; EMA, epithelial membrane antigen; NED, no evidence of the diseade