Fig. 1

CD117⁺CD44⁺CSC vaccine exhibits a potent antitumor activity in mouse ovarian cancer model. a Images exhibits the tumor sizes dissected from the vaccineated mice 47 days after mice were challenged with SKOV3 cells. The nude mice received subcutaneous vaccination in the right flank with 50 μg/ml mitomycin C inactivated 5 × 10⁵ different cell vaccines respectively. A vaccination cycle is consisted of three vaccinations at a biweekly interval. Alive SKOV3 cells (5 × 10⁵) were injected subcutaneously in the left flank 10 days after the final vaccination; b The dynamic state changes of tumor volumes in SKOV3 ovarian cancer beraing nude mice; c Tumor free nude mice challenged with SKOV3 cells