Determination of reference intervals of serum levels of human epididymis protein 4 (HE4) in Chinese women

Table 3 Influences of age, menopause or malignancy on HE levels

Parameter	Number	HE4 Value	P
Parameter	Number	Median (range)	P
Age			<0.001
<40	628	47.275 (15–2982)
40–49	544	51.01 (24.07–4322)
50–59	520	59.47 (26.08–5234)
60–69	371	66.63 (23.3–3844)
≥70	268	84.33 (24.22–2276)
Menopause			<0.001
Pre-menopause	1206	48.81 (15–4322)
Post-menopause	1125	68.46 (23.3–5234)
Malignancy status			<0.001
Healthy	618	51.09 (23.3–166)
Benign	765	51.92 (15–5234)
Malignant	948	67.935 (26.08–4603)
Overall	2331	56.51 (15–5234)

ISSN: 1757-2215