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Table 3 Influences of age, menopause or malignancy on HE levels

From: Determination of reference intervals of serum levels of human epididymis protein 4 (HE4) in Chinese women

Parameter Number HE4 Value P
Median (range)
Age    <0.001
 <40 628 47.275 (15–2982)  
 40–49 544 51.01 (24.07–4322)  
 50–59 520 59.47 (26.08–5234)  
 60–69 371 66.63 (23.3–3844)  
 ≥70 268 84.33 (24.22–2276)  
Menopause    <0.001
 Pre-menopause 1206 48.81 (15–4322)  
 Post-menopause 1125 68.46 (23.3–5234)  
Malignancy status    <0.001
 Healthy 618 51.09 (23.3–166)  
 Benign 765 51.92 (15–5234)  
 Malignant 948 67.935 (26.08–4603)  
Overall 2331 56.51 (15–5234)