Fig. 5

MiR-186 downregulates MDR1 and GST-π expression levels. a MRNA and (b) protein expression levels of MDR1 and GST-π with miR-186 andanti-miR-186 transfection. Results show that mir-186 decreased both mRNA and protein levels of MDR1 and GST-π while anti-miR-186 increased both these levels. However, the MRP1 expression levels did not significantly differ among the groups. Results are representative of three separate experiments. Data are expressed as the mean ± standard deviation. * Compared with miR-C group; # Compared with anti-miR-C group, P < 0.05