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Fig. 3 | Journal of Ovarian Research

Fig. 3

From: Small putative NANOG, SOX2, and SSEA-4-positive stem cells resembling very small embryonic-like stem cells in sections of ovarian tissue in patients with ovarian cancer

Fig. 3

Small NANOG-positive cells (arrows) with diameters of up to 5 μm in “chambers”. These “chambers” containing small, round, NANOG-positive cells were located among epithelial cells in ovarian tissue sections of women with high-grade serous ovarian carcinoma (a-f). The surrounding epithelial cells also became NANOG-positive in some places (d-f), as possibly influenced by small cells in those “chambers”. Controls were provided: negative control (g) and positive control-testicular embryonal carcinoma with strongly stained cells in seminiferous tubules (h) (Light microscope: a, magnification 1000x; inverted microscope: b-h, magnifications 40x, 100x and 200x). Legend: brown-NANOG-positivity, blue-nuclei after HE staining. Red Bar: 10 μm for b-d, 50 μm for f, h and 100 μm for a, e, g

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