Fig. 5
From: The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer
PRSS8 is upregulated in tissues of OVC patients compared to benign and normal tissues. Bar plots of PRSS8 immunostaining score by OVC stage (a) and OVC grade (b); n = number of stained arrays in each group. Immunostaining of all tissue arrays used in this study was score (range: 0–3) according to levels of staining, where score of (0) means negative staining, (1)-weak positive staining, (2)-positive staining, (3)-strong positive staining. Serum samples from OVC (early-stage), benign, and normal subjects (7 in each group) were subjected to western blot for the appearance of PRSS8 and densitometry values for each group were plotted (c). Primary PRSS8 antibody used in this study is a custom-made antibody (see details in Additional file 1)