Table 2 Associations between IGKC, CD20 and CD138 expression and clinicopathological and investigative factors
From: Prognostic impact of tumour-associated B cells and plasma cells in epithelial ovarian cancer
Factor | IGKC expression mean/median (range) | CD20 expression mean/median (range) | CD138 expression mean/median (range) |
|---|---|---|---|
Age | |||
p | 0.886 | 0.879 | 0.067 |
≤Median | 12.34/ 8.75 (0.00–70.00) | 3.16// 0.00 (0.00–40.00) | 9.24/ 5.00 (0.00–60.00) |
>Median | 13.25/7.00 (0.00–105.00) | 2.43/0.00 (0.00–27.00) | 16.53/6.00 (0.00–100.00) |
Histological subtype | |||
p | 0.026 | 0.099 | 0.088 |
Serous | 12.55/7.00 (0.00–1 05.00) | 3.32/0.25 (0.00–40.00) | 12.15/5.25 (0.00–75.00) |
Endometroid | 8.92/4.50 (0.00–60.00) | 2.24/0.00 (0.00–27.00) | 13.76/5.00 (0.00–80.00) |
Mucinous | 10.40/7.50 (0.00–32.00) | 1.08/0.00 (0.00–10.00) | 8.25/1.25 (0.00–70.00) |
Others | 27.81/20.00 (0.00–70.00) | 2.05/0.00 (0.00–18.00) | 15.89/11.00 (0.00–100.00) |
Differentiation grade | |||
p | 0.403 | 0.032 | 0.030 |
Low | 13.50/7.00 (0.00–105.00) | 3.00/0.00 (0.00–27.00) | 13.47/6.75 (0.00–100.00) |
High | 11.14/7.00 (0.00–70.00) | 2.35/0.00 (0.00–40.00) | 11.69/2.50 (0.00–80.00) |
Clinical stage | |||
p | 0.443 | 0.880 | 0.388 |
I | 14.92/8.25 (0.00–70.00) | 3.17/0.00 (0.00–20.00) | 12.38/5.00 (0.00–80.00) |
II | 9.05/7.00 (0.00–32.50) | 3.72/0.00 (0.00–27.00) | 6.33/5.00 (0.00–30.00) |
III | 12.64/7.25 (0.00–70.00) | 2.38/0.00 (0.00–40.00) | 14.64/7.00 (0.00–70.00) |
IV | 15.93/7.25 (0.00–105.00) | 1.81/0.00 (0.00–17.00) | 16.83/5.00 (0.00–100.00) |
KRAS mutation status | |||
p | 0.076 | 0.027 | 0.135 |
Wild-type | 13.26/7.50 (0.00–105.00) | 3.08/0.00 (0.00–40.00) | 13.29/6.00 (0.00–100.00) |
Mutated | 9.50/1.00 (0.00–70.00) | 0.68/0.00 (0.00–10.00) | 10.53/2.50 (0.00–70.00) |