Table 1 Activity of ABT-737, ABT-199 and WEHI-539 in ovarian cancer cell lines cell growth assays. Cells were treated with the indicated BH3 mimetic for 72 h and surviving cell number estimated by staining with SRB. The results are expressed as mean ± S.D. of the number of experiments shown in parentheses
IC50 (μM) | |||
|---|---|---|---|
Cell line | ABT-737 | ABT-199 | WEHI-539 |
OVCAR-8 | 11 ± 5 (12) | 18 ± 6 (13) | 9 ± 5 (11) |
OVCAR-3 | 10 ± 4 (11) | 15 ± 5 (12) | 9 ± 4 (14) |
IGROV-1 | 11 ± 1 (12) | 14 ± 8 (14) | 16 ± 12 (12) |
COV-362 | 17 ± 3 (10) | 4 ± 2 (9) | 12 ± 2 (9) |
OVCAR-4 | 14 ± 5 (8) | 15 ± 2 (7) | 26 ± 9 (7) |
OVSAHO | 7 ± 1 (10) | 17 ± 9 (6) | 14 ± 1 (6) |
COV-318 | 20 ± 3 (5) | 24 ± 2 (3) | 23 ± 5 (3) |
FUOV-1 | 13 ± 1 (4) | 14 ± 6 (3) | 27 ± 4 (3) |